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Medical Research
First developed and put into practice in the United States in
1939, this method of HRT has not yet found their way into the
mainstream of American medicine. This may be primarily due to
the fact that pellets are a compound of all natural components,
rather than a laboratory - created substance and cannot be
patented.
It is NOT because there is any lack of evidence for how well
this therapy works, as shown in the following statements. Even
though the references made here are technical in nature, we do this so
that you will see that SottoPelle® is not just some
"mystical alternative" to traditional medicine. Pellet therapy
has been heavily studied and researched, particularly in England
and continues to enjoy ever-increasing use by women and men throughout
various parts of the world, particularly in England, Australia, and now
in the United States.
"Pellet therapy provides "near-ideal [storage] properties and
prolonged duration of action" and "has few minor and no major
side-effects observed in more than 650 implant procedures over a
period of 10 years." - DAVID J. HANDELSMAN, PHARMACOLOGY,
BIOLOGY, AND CLINICAL APPLICATIONS OF ANDROGEN, 1994
"Implants bypass the intestine, avoiding the first-pass effect
on liver metabolism of the hormone. This prevents the
unphysiological ratio of oestradiol to oesterone found with oral
preparations." - THOM/STUDD--1978
"Oral preparations, unlike implants, also reduce liver
metabolism of clotting factors and lipids." - Elkik/Gompel
"…oral estrogen in general increases vertebral bone density by
approximately 1-2% per annum, whereas the 75mg oestradiol
implant, which achieves oestradiol levels in general at least
double those of oral therapy, has been shown to increase vertebral
bone density by 8.3% per annum. - SMITH/STUDD, BRITISH JOURNAL OF HOSPITAL
MEDICINE, 1993
"Testosterone pellet implants have many of the ideal features of
a long-acting androgen depot [storage], including being safe,
highly effective with stable clinical and bio-chemical effects,
economical, providing flexible dosing, and excellent long-acting
properties due to a near-zero-order dissolution. A single
biodegradable implant of 600-1200 mg provides stable, effective,
and well-tolerated replacement for 4-6 months and pellets can
provide excellent androgen replacement in most physiological
settings." - DAVID J. HANDELSMAN, PHARMACOLOGY, BIOLOGY, AND
CLINICAL APPLICATIONS OF ANDROGEN, 1994
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